Basement membrane stiffness determines metastases formation

Evaluation of Basement Membrane Formation on Bruch’s Membrane Implants

The long-term success of an implant may be dependent on the production of a stable basement membrane and it may be desirable to reproduce the structure of healthy Bruch’s membrane. We hypothesise that the substrate surface chemistry will influence RPE extracellular matrix (ECM) production. The aim of this work was to investigate the distribution of ECM proteins produced by primary human RPE cel...

Basement membrane.

Basement membrane has attracted less attention than the other components of connective tissue. But, like the other extracellular fibres and matrix materials, it can profoundly influence both the structure and function of advanced life forms. Usually taking the shape of thin, structureless cementing material between epithelial and connective tissue, basement membranes are widely distributed thro...

Basement Membrane

We report a case of struma ovarii with hyperthyroidism and elevated serum concentrations of type IV collagen and laminin. Circulating levels of type IV collagen and laminin were measured using specific radioimmunoassays (RIAs) for 7S collagen and the P-1 fragment of laminin, and the basement membrane components in the tumor were investigated by immunohistochemical analysis. Strong immunohistoch...

Possible Diverse Roles of Fukutin: More Than Basement Membrane Formation?

Fukutin is a gene responsible for Fukuyama-type congenital muscular dystrophy (FCMD) (Kobayashi et al. 1998). FCMD is associated with ocular and central nervous system (CNS) malformation characterized by cobblestone lissencephaly (Fukuyama et al. 1960; Osawa et al. 1997), and is included in -dystroglycanopathy, one of the groups of muscular dystrophy. -dystroglycan (-DG) is one of the compon...

Basement membrane collagen.